Summary of the International Society for Heart and Lung Transplantation (ISHLT) Consensus Conference on Graft Dysfunction within the First 72 hours after Heart Transplantation: A 10-year Update - PubM
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- #Primary Graft Dysfunction
- #Heart Transplantation
- #Medical Consensus
- Primary graft dysfunction (PGD) is a major cause of early mortality post-heart transplantation, defined as ventricular dysfunction within 24 hours without secondary causes.
- Over the past decade, advancements include better understanding of PGD classification, risk factors, and improvements in donor heart preservation and mechanical circulatory support.
- Current risk-stratification tools for PGD have limitations and perform poorly in contemporary settings.
- Prevention and management strategies for PGD vary by center and lack objective data, with vasoplegia often complicating PGD cases.
- A 2024 ISHLT consensus conference aimed to update PGD definitions, grading, and provide guidance on risk mitigation and treatment strategies.
- The conference emphasized the need for future studies to build on the consensus findings.