Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities - PubMed
5 hours ago
- #PRP
- #Regenerative Medicine
- #Exosomes
- Regenerative medicine targets shared biological mechanisms for musculoskeletal disorders and hair follicle dysfunction.
- Conditions like tendinopathies, osteoarthritis, and alopecia have significant physical and psychosocial impacts.
- Conventional therapies often provide limited or symptomatic relief.
- The review focuses on platelet-rich plasma (PRP), exosomes, and physical modalities like low-level laser therapy (LLLT) and mechanotransduction.
- These modalities modulate stem cell activity, angiogenesis, inflammatory signaling, and extracellular matrix remodeling.
- Shared molecular pathways include Wnt/β-catenin, TGF-β, IGF-1, PDGF, and VEGF signaling.
- Overlapping regenerative mechanisms enable translational application across orthopedic and dermatologic contexts.
- The review highlights clinical evidence, practical considerations, and regulatory challenges.
- Gaps in standardization, dosing, and outcome measures are identified.
- The aim is to advance biologically driven, minimally invasive therapies for true tissue regeneration.