Single-nucleus transcriptomics of an engineered pig model reveals microglia-T cell interactions driving Huntington's disease neurodegeneration - PubMed
4 hours ago
- #immune response
- #Huntington's disease
- #neurodegeneration
- Engineered pig model with human huntingtin mutation used to study Huntington's disease neurodegeneration.
- Single-nucleus and spatial transcriptomics reveal interferon-responsive microglia secreting chemokine ligand eight.
- Chemokine ligand eight recruits cytotoxic CD8-positive T cells, accelerating neuronal loss.
- Neutralization of chemokine ligand eight mitigates neurodegeneration, suggesting a therapeutic target.
- Findings highlight a species-dependent immune mechanism in Huntington's disease.