Oxidative stress reprograms benign prostatic hyperplasia microenvironments: insights from integrative multi-omics and machine learning - PubMed
19 hours ago
- #BPH biomarkers
- #multi-omics analysis
- #oxidative stress
- Identified three oxidative stress-related hub genes (ACOX2, CTSB, SERPINF1) with high diagnostic potential for benign prostatic hyperplasia (BPH), though findings are hypothesis-generating due to small sample size.
- Characterized two BPH subtypes (immune-infiltrated vs. non-immune) using multi-omics and revealed elevated oxidative stress scores in fibroblasts, particularly ACOX2-high fibroblasts, through single-cell and spatial transcriptomics.
- Experimental validation showed that ACOX2 overexpression promotes proliferation and reduces apoptosis in prostatic stromal cells under oxidative stress, with upregulated ACOX2 expression confirmed in human hyperplastic prostate tissues.