Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model - PubMed

4 hours ago

Parkinson's disease (PD) is characterized by alpha-synuclein aggregation, dopaminergic degeneration, and pathological beta oscillations (13-30 Hz) in the basal ganglia.
Deep brain stimulation (DBS) is an effective treatment for PD motor symptoms, but its mechanism in mitigating beta oscillations is unclear.
The A53T alpha-synuclein rat model replicates PD-like electrophysiological features, including early beta oscillations in the motor cortex spreading to subthalamic and entopeduncular nuclei.
Beta oscillations in the model manifest as transient bursts during the awake state.
Low- and high-frequency DBS differentially modulate beta bursts and motor performance, suggesting potential for optimized therapies targeting aberrant beta activity.

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