Clinical benefits and risks of high-dose intravenous vitamin C: a systematic review - PubMed
7 hours ago
- #Vitamin C
- #Clinical Review
- #Intravenous Therapy
- High-dose intravenous vitamin C (IVC) achieves higher plasma concentrations than oral administration.
- IVC has been studied as an adjunct in sepsis, oncology, and symptom management.
- Potential benefits include antioxidant effects, immune modulation, and downregulation of pro-inflammatory pathways.
- Oncology studies show safety and quality-of-life improvements, with some survival benefits in pancreatic cancer.
- Risks include oxalate nephropathy and hemolysis in G6PD-deficient patients.
- Pre-screening is recommended to mitigate risks.
- Home infusion services are expanding, but clinical outcome data for IVC in these settings are limited.
- Routine use of high-dose IVC in sepsis is not supported by current evidence.
- IVC's role in oncology remains supportive and exploratory.