Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis - PubMed
7 hours ago
- #TFEB activation
- #ALS
- #lysosomal function
- Isoginkgetin (ISO) is identified as a TFEB activator that promotes mTORC1-independent TFEB nuclear translocation.
- ISO functions as an ATP-competitive inhibitor of GSK-3β, binding to Lys85 to regulate the GSK-3β-TFEB axis.
- ISO enhances lysosomal biogenesis and function, protecting ALS motor neurons from degeneration.
- Lysosomal dysfunction is highlighted as a druggable target for ALS.
- The study utilized AI-powered computational virtual screening to discover ISO.