Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization - PubMed
4 hours ago
- #depression
- #gut-microbiota
- #microglia
- Muribaculum intestinale (M. intestinale) alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization.
- Loganin, a potential antidepressant, modulates gut microbiota, increasing Muribaculum abundance and short-chain fatty acids (SCFAs).
- Fecal microbiota transplantation (FMT) from loganin-treated donors and M. intestinale administration showed antidepressant-like effects in mice.
- M. intestinale promotes butyrylation of RORγt, inhibiting Th17 cell differentiation and suppressing M1 microglia polarization.
- Overexpression of RORγt attenuates the behavioral benefits of M. intestinale, highlighting its role in depression alleviation.
- The study suggests M. intestinale as a promising microbial-based therapeutic strategy for depression.