SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease - PubMed
5 hours ago
- #Ferroptosis
- #SIRT1
- #Diabetic Kidney Disease
- SIRT1 expression is reduced in diabetic kidney disease (DKD), correlating with increased lipid deposition in renal tubules.
- SIRT1 deficiency impairs mitophagy and exacerbates ferroptosis in renal tubular cells under lipotoxic stress.
- Overexpression of SIRT1 restores mitophagy, alleviates ferroptosis, and mitigates DKD progression.
- Inhibitors confirm the protective role of SIRT1-mediated mitophagy against ferroptosis in DKD models.