Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells - PubMed
4 hours ago
- #paracrine signaling
- #glucagon secretion
- #type 1 diabetes
- Paracrine inhibition via G protein inwardly rectifying potassium channels (GIRK) regulates glucagon secretion in human pancreatic alpha cells.
- Impaired glucagon secretion in type 1 diabetes (T1D) is linked to loss of paracrine signals from beta (5-HT, GABA) and delta (SST) cells.
- Paracrine signals activate GPCRs, opening GIRK channels, which are crucial for maintaining glucagon secretion.
- Without paracrine inhibition, glucagon secretion diminishes and eventually habituates.
- 5-HT, GABA, and SST restored impaired glucagon secretion in T1D donor islets.
- Beta cell destruction in T1D leads to loss of paracrine inhibition, impairing alpha cell glucagon secretion and glucose counter-regulation.