Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates - PubMed
12 hours ago
- #Vitamin C
- #ferro-aging
- #ACSL4
- Aging in primates is linked to oxidative stress and an iron-lipid axis termed 'ferro-aging'.
- Age-related iron accumulation leads to lipid peroxidation, driven by ACSL4, promoting cellular senescence and functional decline.
- Inhibition of hepatic ACSL4 via gene editing reduces aging phenotypes in mice.
- Vitamin C (VC) is identified as a direct inhibitor of ACSL4.
- Long-term VC administration in aged monkeys reduces ferro-aging markers, improves organ function, and reverses biological age.
- VC is proposed as a geroprotective strategy targeting ACSL4 to alleviate primate aging.