Towards biomarker-based diagnosis of Parkinson disease - PubMed
8 days ago
- #biomarkers
- #diagnosis
- #Parkinson disease
- Current clinical diagnostic criteria for Parkinson disease (PD) have limitations and are insensitive to early stages.
- Imaging and genetic tests support PD diagnosis, but no validated biomarker-based framework exists.
- Seed amplification assays (SAAs) detect low levels of pathological α-synuclein in biofluids and tissues.
- Biomarkers like α-synuclein SAAs could improve diagnostic accuracy and enable earlier PD diagnosis.
- Research focuses on predictive biomarkers for PD in healthy and prodromal individuals.
- Integration of clinical, genetic, molecular, and imaging biomarkers could enable personalized PD treatment.