Improving Cognition in Bipolar Disorder: A Systematic Review of Current Pharmacological and Nutraceutical Approaches - PubMed
3 hours ago
- #pharmacological interventions
- #bipolar disorder
- #cognitive impairment
- Cognitive impairment is a core feature of bipolar disorder (BD) affecting functioning and quality of life.
- Systematic review evaluates pharmacological and nutraceutical interventions for cognitive deficits in BD.
- 16 studies included, assessing 13 different agents on cognition in euthymic or partially remitted BD patients.
- Galantamine showed consistent benefits for verbal learning and memory.
- Lithium, tianeptine, ashwagandha, insulin, and lurasidone demonstrated cognitive benefits in single studies.
- Erythropoietin and pramipexole had mixed results; other agents like modafinil and quetiapine showed no significant effects.
- Study quality varied from good to poor, but safety and tolerability of agents were generally favorable.
- Need for larger, controlled trials with uniform cognitive assessments to confirm findings and clinical relevance.