Selenoprotein thioredoxin reductase 1 promotes cancer cells ferroptosis by suppressing GPX4 expression - PubMed
4 hours ago
- #thioredoxin reductase
- #cancer therapy
- #ferroptosis
- Ferroptosis is a type of regulated necrosis driven by iron-dependent lipid peroxide accumulation.
- Thioredoxin reductase 1 (TrxR1) promotes ferroptosis by suppressing GPX4 expression.
- TrxR1 stabilizes KEAP1, leading to NRF2 degradation and downregulation of GPX4.
- High TrxR1 levels sensitize cancer cells to ferroptosis in vivo.
- Combination therapy with CRBN inhibitor thalidomide and IKE slows tumor progression.
- TrxR1 is a potential biomarker for ferroptosis-inducing therapies in certain cancers.