Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids - PubMed
3 hours ago
- #Cancer Stem Cells
- #Chemoresistance
- #Ovarian Cancer
- Ovarian cancer (OC) is often diagnosed late, with tumor heterogeneity and chemoresistance leading to poor prognosis.
- Patient-derived organoids (PDOs) from ascites samples accurately replicate tumor features and predict drug responses.
- PDOs showed an 86.2% success rate and maintained histopathological and genomic fidelity to original tumors.
- Oncolytic herpes simplex virus 2 (OH2) combined with cisplatin reduced cancer stem cell (CSC) populations and enhanced efficacy.
- OH2 alone reduced cell viability by 20-60% in both cisplatin-sensitive and resistant PDOs.
- The study suggests PDOs as a reliable platform for personalized drug testing in OC treatment.