Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction - PubMed
4 hours ago
- #Guideline-Directed Medical Therapy
- #Retrospective Cohort Study
- #Heart Failure
- The study focuses on the time to achieve quadruple guideline-directed medical therapy (GDMT) after an initial diagnosis of heart failure with reduced ejection fraction (HFrEF).
- Only 21.2% of patients achieved quadruple therapy over a median follow-up of 2.9 years, with a median time to therapy of 197 days.
- Black and Hispanic patients had higher rates of achieving quadruple therapy compared to White patients, while sex did not significantly affect the time to therapy.
- Prescription copays were associated with an 8% lower rate of achieving quadruple therapy, indicating a modifiable barrier.
- Factors like outpatient diagnosis, presence of diabetes, and absence of chronic kidney disease were linked to higher rates of quadruple therapy.