ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata - PubMed
9 hours ago
- #Alopecia Areata
- #Hydrogel Delivery
- #STAT3 Inhibition
- Alopecia areata (AA) is an autoimmune disorder driven by IFN-γ and CD8+ T-cell infiltration, with overactivation of the JAK-STAT pathway.
- miR-665 was identified as a regulator of STAT3, delivered via a ROS-responsive hydrogel (PVA-TSPBA) for localized and sustained treatment.
- The hydrogel showed excellent injectability, ROS-dependent degradation, and sustained miR-665 release, counteracting IFN-γ effects in vitro.
- In vivo, PVA-TSPBA@miR-665 promoted hair regeneration, restored follicular structure, and reduced T-cell infiltration in AA mice.
- This study presents a novel miRNA-biomaterial strategy for targeted, durable, and safe AA treatment.