GLP-1 Receptor Agonists - PubMed
5 hours ago
- #GLP-1 agonists
- #weight loss
- #type 2 diabetes
- GLP-1 receptor agonists are incretin analogues that promote glucose-mediated insulin release and treat type 2 diabetes and obesity.
- Mechanisms of action include reducing gastric emptying, inhibiting glucagon secretion, altering the gut microbiome, and enhancing satiety to promote weight loss.
- Clinical trials demonstrate benefits such as cardiovascular risk reduction and slowing renal failure progression in high-risk individuals with type 2 diabetes.
- Side effects are primarily gastrointestinal and may include loss of muscle and bone mass; long-term adherence and weight regain post-discontinuation are concerns.
- Ongoing research explores additional therapeutic applications for GLP-1 receptor agonists.