Natural products targeting the gut-brain axis for the treatment of post-cardiac procedures anxiety or depression - PubMed
3 hours ago
- #Post-cardiac depression
- #Gut-brain axis
- #Natural products
- Post-cardiac surgery anxiety or depression (PCPAD) is a common neuropsychiatric complication with significant risks.
- The gut-brain axis (GBA) plays a key role in PCPAD pathogenesis, involving gut microbiota dysbiosis and neuroimmune interactions.
- Natural products, including TCM and other plant-based compounds, can target GBA through multiple mechanisms to treat PCPAD.
- These mechanisms include promoting beneficial bacteria, anti-inflammatory effects, repairing intestinal barriers, and regulating neurotransmitters.
- Natural products offer advantages like high biocompatibility, low toxicity, and suitability for post-surgery recovery.
- Future research should focus on large-scale clinical trials, toxicology studies, and standardizing treatments for clinical translation.