Alcohol consumption, smoking, and the implications of their cessations for field carcinogenesis in the esophagus: a 10-year prospective cohort study - PubMed
5 days ago
- #Behavioral Intervention
- #Esophageal Cancer
- #Carcinogenesis
- Alcohol and tobacco are established carcinogens promoting field carcinogenesis for esophageal squamous cell carcinoma (ESCC).
- A 10-year prospective cohort study evaluated the long-term effects of alcohol and tobacco cessation on metachronous ESCC (mESCC) risk post-endoscopic resection (ER).
- Patients were stratified by Lugol-voiding lesion (LVL) grade (A: none, B: 1-9, C: ≥10), with cumulative mESCC incidences of 10.4%, 27.2%, and 61.8% respectively.
- Increased alcohol consumption and higher LVL grades independently raised mESCC risk.
- Alcohol or smoking cessation reduced mESCC risk (HR 0.52 and HR 0.44 respectively), with combined cessation showing the greatest impact (HR 0.21).
- Complete cessation, not partial reduction, was necessary for meaningful risk reduction.
- Behavioral interventions for complete cessation are crucial for secondary prevention of field carcinogenesis post-ER.