Metformin Attenuates Osteoarthritis Progression by Modulating Mitochondrial Dynamics via Activation of the AMPK/Drp1 Pathway - PubMed
4 hours ago
- #Osteoarthritis
- #Metformin
- #AMPK/Drp1 Pathway
- Metformin mitigates osteoarthritis progression by activating AMPK, which influences mitochondrial dynamics through the Drp1 pathway.
- The drug reduces oxidative stress and NLRP3 inflammasome activation, restoring chondrocyte function and promoting mitophagy.
- Findings suggest metformin's therapeutic potential for OA via mitochondrial modulation, offering a novel treatment target.