DLK, NMNAT2, and SARM1: Judge, Jury, and Executioner in Axon Degeneration - PubMed
4 hours ago
- #therapeutic targets
- #axon degeneration
- #neurodegeneration
- Axon degeneration is a regulated process central to neurodegenerative diseases.
- DLK, NMNAT2, and SARM1 form a molecular axis for axonal self-destruction.
- DLK initiates MAPK signaling to express prodegenerative genes upon stress.
- NMNAT2 depletion post-injury leads to NMN accumulation, activating SARM1.
- SARM1 is the central executioner of axon degeneration.
- Targeting DLK, NMNAT2, and SARM1 offers therapeutic opportunities for neurodegenerative disorders.