Lipoprotein(a), Atherosclerotic Plaque Burden, and Long-term Cardiovascular Outcomes in Patients With Coronary Artery Disease - PubMed
7 hours ago
- #Lipoprotein(a)
- #Cardiovascular Outcomes
- #Atherosclerotic Plaque
- Lipoprotein(a) [Lp(a)] is an established independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in primary prevention settings.
- The study combined data from ATHEROREMO and IBIS-3 observational studies, involving 798 patients undergoing coronary angiography.
- Patients with Lp(a) > 125 nmol/L had higher IVUS-derived plaque burden but no significant associations with other plaque characteristics.
- No association was found between Lp(a) levels and 5-year major adverse cardiac events or 10-year all-cause mortality.
- Higher Lp(a) levels were linked to increased plaque burden but did not result in more adverse cardiovascular events or deaths.
- Most patients were on cholesterol-lowering therapy, which may have mitigated any additional risk from elevated Lp(a).
- Larger studies and trials of Lp(a)-lowering treatments are needed to determine if lowering Lp(a) improves outcomes.