IFNγ-induced antigen loss in chimeric antigen receptor-T cell therapy - PubMed
5 hours ago
- #IFNγ
- #CAR-T therapy
- #antigen escape
- IFNγ, typically beneficial for T-cell functions, induces antigen loss in colorectal cancer cells, limiting CAR-T therapy efficacy.
- Mechanism involves IFNγ receptor, JAK, and stress pathways, and can be reversed with anti-IFNγ antibodies, ruxolitinib, or 4-phenylbutyrate.
- This negative effect of IFNγ impacts immunotherapies targeting native surface antigens like CAR-T and BiTE, suggesting stress pathway disruption as a strategy to enhance solid tumor treatments.