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Research Team Discovers Natural Immune Mechanism That Stops Metastatic Cancer

18 days ago
https://montefioreeinsteinnow.org/update/2025-aug-6/research-team-discovers-natural-immune-mechanism-stops-metastatic-cancer
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  • #metastasis
  • #immune-system
  • #cancer-research
  • Disseminated cancer cells (DCCs) can remain dormant or aggressively form metastases.
  • Alveolar macrophages in the lungs secrete TGF-β2 to keep DCCs dormant.
  • Depleting alveolar macrophages increases DCC activation and metastasis in mice.
  • Aggressive DCCs can resist dormancy signals, leading to metastasis.
  • Understanding immune regulation of DCC dormancy could lead to new therapies.
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