The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor - PubMed
2 hours ago
- #Ferroptosis
- #Piezo1
- #Mechanotransduction
- Piezo1 is a mechanically activated cation channel sensitive to membrane tension and permeable to calcium (Ca2+).
- Piezo1 activation leads to Ca2+ influx, reprogramming iron metabolism and promoting ROS accumulation and lipid peroxidation, leading to ferroptosis.
- The 'mechanical force-Piezo1-Ca2+-iron/lipid metabolism' axis links mechanical stress to ferroptosis and integrates mechanotransduction with inflammatory responses and metabolic reprogramming.
- Piezo1-mediated ferroptosis has context-dependent effects in diseases like musculoskeletal degeneration, ischemia-reperfusion injury, IBD, neurovascular disorders, and cancer.
- Current interventions target Piezo1 inhibition, Ca2+ signaling, iron chelation, lipid peroxidation suppression, and GPX4/CoQ10 axis preservation.
- Understanding Piezo1-ferroptosis dynamics could lead to novel therapeutic targets and precision treatments for mechanosensitive diseases.