MHC class I on target cells regulates CD4+ T cell-mediated immunity - PubMed
4 hours ago
- #CD4+ T cells
- #MHC class I
- #immunity
- MHC class I on target cells modulates CD4+ T cell-mediated immunity.
- Absence of MHC class I increases susceptibility of target cells to CD4+ T cell cytotoxicity.
- Enhanced ferroptosis of target cells contributes to increased CD4+ T cell-mediated cytotoxicity.
- CD4+ T cells enhance immune checkpoint blocker responses in cancers with downregulated MHC class I.
- Findings expand the role of MHC class I beyond CD8+ T cell and NK cell immunity.