p16High-expressing immune cells control disease tolerance as a defense and health span-extending strategy - PubMed
3 hours ago
- #Disease Tolerance
- #Healthspan Extension
- #p16High Immune Cells
- p16High immune cells play a crucial role in disease tolerance, limiting tissue damage without reducing pathogen load.
- BNT162b2 mRNA COVID-19 vaccine induces p16High immune subsets in mice and humans, protecting against endotoxin shock, sepsis, and radiation.
- Mechanisms involve TLR7 activation or low-level STING signaling, reducing adenosine via NNMT regulation and maintaining tissue homeostasis.
- Ifih1 deletion boosts STING activation, expands p16High cells, enhances resilience to inflammation, and delays aging-related organ decline.