Evaluation of plasticizer toxicity effects and mechanisms in gastric cancer based on network toxicology and molecular docking - PubMed
4 hours ago
- #molecular docking
- #gastric cancer
- #network toxicology
- Study evaluates toxicity effects and mechanisms of plasticizers (DBP and DEP) in gastric cancer using network toxicology and molecular docking.
- Identified 143 relevant targets through multiple databases and constructed a network diagram.
- Utilized GO functional annotations, KEGG pathway enrichment, and PPI networks to analyze biological pathways and central genes.
- Molecular docking showed strong binding affinity between plasticizers and key genes (PIK3CG, PIK3CD, JAK2, HRAS, PTPN11).
- Highlights plasticizers as potential environmental triggers for gastric cancer, emphasizing the role of network toxicology in assessing environmental pollutants.