Induction and regulation of reversible suspended animation in C. elegans - PubMed
4 hours ago
- #C. elegans
- #stress-resilience
- #suspended-animation
- A new form of reversible suspended animation, called LISA, can be induced in C. elegans by high population density in isosmotic liquids.
- LISA involves profound metabolic, behavioral, and developmental quiescence, with changes in gene expression, energy metabolites, and organelle morphology.
- Genetic screens identified mutants with altered stress responses and survival, with endo-lysosomal regulators promoting survival during LISA.
- Awakening from LISA is regulated by organelle remodeling and a neuronal axis involving neuropeptide and cAMP/PKA signaling.