Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial - PubMed
4 days ago
- #brain metastases
- #clinical trial
- #radiation therapy
- The study compares stereotactic radiation (SR) and hippocampal-avoidance whole brain radiation (HA-WBRT) for treating 5-20 brain metastases.
- SR showed better outcomes in symptom severity and daily functioning interference compared to HA-WBRT over 6 months.
- The mean change in symptom scores was -0.32 for SR vs. +0.74 for HA-WBRT, with a significant difference favoring SR.
- Adverse events were similar between groups (12% SR vs. 13% HA-WBRT), with fatigue being the most common side effect.
- SR is recommended over HA-WBRT for improving quality of life in patients with multiple brain metastases.