Cyclic vomiting syndrome - PubMed
9 hours ago
- #Pediatric gastroenterology
- #Migraine
- #Cyclic vomiting syndrome
- Cyclic vomiting syndrome (CVS) is characterized by recurrent vomiting episodes.
- Mean ages at onset and diagnosis in children are 5.7 and 8.0 years, respectively, with an average delay of 2.3 years in diagnosis.
- Prevalence of CVS ranges from approximately 0.3% to 2%.
- Pathophysiology, prognosis, and natural history of CVS require further investigation.
- No randomized control study on abortive therapy for CVS has been conducted yet.
- NASPGHAN 2025 guidelines recommend specific acute and preventive treatments for CVS in children.
- Acute treatments include non-steroidal anti-inflammatory drugs, triptans, ondansetron, aprepitant, and fosaprepitant.
- Preventive treatments include coenzyme Q10, riboflavin, magnesium, propranolol, cyproheptadine, aprepitant, and amitriptyline.
- Antiseizure medications like topiramate and valproic acid are not recommended unless patients are unresponsive to other treatments.