Single-cell spatial atlas of the aging human breast - PubMed
4 hours ago
- #immunology
- #breast aging
- #spatial atlas
- Aging human breast tissue becomes less cellular and less proliferative across all cell types.
- Tissue architecture changes include fewer heterotypic epithelial interactions, reduced lobules, and increased fat.
- Older tissues exhibit a more inflammatory microenvironment with more M2 macrophages and granzyme B+ T cells.
- Younger tissues are enriched with B cells, contrasting the immune profile of aged breasts.
- The study uses imaging mass cytometry to analyze over 3 million cells from 527 reduction mammoplasties.