Peritoneal cancer risk after risk reducing salpingo-oophorectomy, impact of mutational status and STIC lesions - PubMed
7 hours ago
- #BRCA1/2
- #STIC
- #RRSO
- Women with BRCA1/2 pathogenic variants have a high lifetime risk of ovarian cancer.
- Risk-reducing salpingo-oophorectomy (RRSO) is recommended between ages 35-45 for BRCA1/2 carriers.
- A study of 1351 high-risk women (984 BRCA1/2 carriers) found STIC lesions in 14 patients at RRSO.
- The 5-year cumulative incidence of peritoneal carcinoma (PC) was 0.4% overall and 0.5% among BRCA1/2 carriers.
- Age at surgery was significantly associated with pathological findings (invasive carcinoma, STIC, benign lesions).
- Women with STIC at RRSO had a 5-year PC risk of 11.1%.
- Early RRSO, meticulous tubal evaluation, and extended surveillance are crucial for at-risk women.
- Detection of STIC requires tailored follow-up strategies.
- Further studies are needed to assess the effectiveness of staging surgery or monitoring with CA125/ctDNA.