Tau pathology in epilepsy: emerging mechanisms and translational opportunities - PubMed
4 hours ago
- #epilepsy
- #tau pathology
- #neurodegeneration
- Epilepsy onset in adulthood is most common after 55 years, increasing healthcare burden due to global aging.
- A bidirectional link exists between epilepsy and dementia, with tau pathology as a potential mechanistic connection.
- Tau protein's biochemical and structural changes can lead to abnormal phosphorylation and pathological aggregation.
- Tau's role in seizures and cognitive difficulties is examined from animal models to human epileptic syndromes.
- Seizure prevalence is evaluated across primary and secondary tauopathies to understand hyperexcitability phenotypes.
- Neurophysiology, metabolic imaging, and fluid biomarkers are discussed as non-invasive measures for neurodegeneration in epilepsy.
- Clinical trials targeting pathological tau in neurodegenerative conditions, including sodium selenate, are explored.
- There's a need for deeper characterization of tau pathology in epilepsy to understand its role in pathogenesis and dementia.