Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review) - PubMed
3 hours ago
- #neurodegeneration
- #iron-homeostasis
- #ferroptosis
- Ferroptosis, an iron-dependent form of cell death, plays a key role in neurodegenerative diseases like Alzheimer's and Parkinson's.
- Ferritin regulates iron homeostasis by sequestering excess iron, protecting cells from Fenton reaction toxicity.
- Ferritinophagy, the degradation of ferritin, releases toxic iron, triggering ferroptosis and contributing to neurodegeneration.
- Ferritin may serve as a biomarker for early diagnosis and a target for therapeutic strategies in neurodegenerative diseases.
- MRI-based non-invasive quantification of cerebral iron deposition offers clinical translational value for monitoring disease progression.