Hippocampal Hap1 downregulation exacerbates Alzheimer's disease-related neuropathology through impairment of glucocorticoid receptor nuclear translocation in APP/PS1 mice - PubMed
4 days ago
- #Alzheimer's disease
- #Glucocorticoid receptor
- #Synaptic plasticity
- Hippocampal Hap1 downregulation worsens Alzheimer's disease (AD) neuropathology in APP/PS1 mice.
- Hap1 regulates glucocorticoid receptor (GR) nuclear translocation in the hippocampus.
- Hap1 expression decreases with aging and AD progression in APP/PS1 mice.
- Hap1 knockdown leads to cognitive deficits, synaptic loss, and increased Aβ deposition.
- Hap1 deficiency disrupts GR nuclear translocation and BDNF transcription.
- Hap1 knockdown elevates corticosterone levels and causes depressive-like behaviors.
- Hap1-mediated GR nuclear translocation is a key mechanism in AD synaptic failure.
- Hap1 modulation is suggested as a potential therapeutic target for AD.