MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism - PubMed
a day ago
- #ferroptosis
- #podocyte
- #diabetic nephropathy
- MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via glycerophospholipid metabolism in diabetic nephropathy (DN).
- Single-cell RNA sequencing identifies podocytes as central to DN, with dysregulation in ferroptosis and glycerophospholipid metabolism.
- Astragaloside IV (ASIV) shows protective effects by targeting ferroptosis, reversing diabetic transcriptional changes, and preserving podocyte integrity.
- Spatial metabolomics reveals metabolic dysregulation in renal cortex and medulla, regulated by ASIV.
- Urinary metabolic intermediates of glycerophospholipid metabolism are identified as non-invasive biomarkers for DN diagnosis.