Alteration of gut microbiota contributes to peritoneal fibrosis through increased production of trimethylamine N-oxide - PubMed
4 hours ago
- #TMAO
- #Gut Microbiota
- #Peritoneal Fibrosis
- Peritoneal fibrosis is a common complication in peritoneal dialysis (PD) patients, leading to ultrafiltration failure and PD withdrawal.
- Altered gut microbiota and elevated serum trimethylamine N-oxide (TMAO) levels are observed in PD mice, with gut microbiota depletion ameliorating peritoneal fibrosis.
- Fecal microbiota transplantation from PD patients, especially those with ultrafiltration failure, induces peritoneal mesenchymal and fibrotic changes in mice.
- TMAO supplementation enhances PD-induced peritoneal fibrosis, while knockout of flavin-containing monooxygenase 3 (which prevents TMAO synthesis) reduces fibrosis.
- TMAO promotes high glucose-mediated phenotypic transition and fibrogenesis in peritoneal cells by increasing TGF-β1 and activating Smad2/3 and Wnt/β-catenin pathways.