Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications - PubMed
5 hours ago
- #extrachromosomal DNA
- #biomarker
- #urothelial carcinoma
- Extrachromosomal DNA (ecDNA) drives genomic instability and rapid tumor evolution in urothelial carcinoma.
- ecDNA amplifies oncogenes, reshapes chromatin interactions, reprograms transcription, and modulates the tumor-immune interface in urothelial carcinoma.
- These features contribute to intratumoral heterogeneity, accelerate APOBEC3-associated mutational evolution, and lead to aggressive disease.
- Advances in sequencing and imaging technologies have improved understanding of ecDNA biology.
- ecDNA can be detected non-invasively via liquid biopsies (urine, plasma) and inferred from histopathology slides using digital pathology.
- ecDNA has potential as a biomarker for early detection, patient stratification, and monitoring treatment response in urothelial carcinoma.