SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation - PubMed
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- SETDB1 and HUSH complex suppress Xist transcription during X chromosome inactivation (XCI) establishment by depositing H3K9me3.
- Depletion of SETDB1 or HUSH subunits increases Xist transcription, RNA accumulation, and accelerates X-linked gene silencing.
- The SETDB1/HUSH pathway regulates Xist RNA levels to ensure inactivation of only one X chromosome in female cells.