Impact of pharmaceutical intervention on the use of intravenous antibiotics in patients with bacterial upper respiratory tract infections: protocol for a cluster-randomized controlled trial - PubMed
4 hours ago
- #Antimicrobial Stewardship
- #Respiratory Infections
- #Clinical Trial Protocol
- The study addresses the overuse of intravenous antibiotics in bacterial upper respiratory tract infections (URTIs), particularly prevalent in China.
- A pharmacist-led, multidimensional intervention including physician training, clinical decision support, and patient education will be tested in a cluster-randomized controlled trial.
- Primary outcome: rate of intravenous antibacterial drug infusion during hospital admission; secondary outcomes include symptom duration, adverse events, and re-consultation rates.
- Trial involves 28 hospitals in Zhejiang Province, China, with participants enrolled from August 2025 to January 2026, and follow-up completed 14 days post-discharge.
- Aim: Evaluate feasibility and impact of intervention on reducing intravenous antibiotic use in URTI patients, with results potentially informing antimicrobial stewardship strategies.