Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke-depression comorbidity - PubMed
5 hours ago
- #depression
- #ketamine
- #ischemic stroke
- Study focuses on ketamine's molecular mechanisms in ischemic stroke-depression comorbidity.
- Used network pharmacology and bioinformatics to identify ketamine's targets and pathways.
- Identified 42 intersecting genes from ischemic stroke and major depressive disorder datasets.
- Key pathways include lipid and atherosclerosis, interleukin-17 signaling, and cellular response to stimuli.
- IL1RN and DDIT3 emerged as central genes linked to immune regulation and neurotrophin signaling.
- Molecular docking suggested ketamine may bind to IL1RN and DDIT3 proteins.
- Findings propose ketamine modulates multiple pathways, offering a framework for future validation.