The XSER1 lncRNA acts as an enhancer RNA and confers resistance to pathogens by promoting chromatin loop formation in rice - PubMed
3 hours ago
- #lncRNA
- #disease resistance
- #chromatin looping
- XSER1 lncRNA acts as an enhancer RNA (lnc-eRNA) in rice, conferring resistance to pathogens.
- XSER1 is quickly activated upon pathogen infection and binds to transcription factor OsbHLH94.
- Promotes chromatin loop formation, affecting chromatin accessibility and gene expression.
- Regulates adjacent gene OsJMJ707, a histone H3 lysine 4 (H3K4) demethylase, enhancing disease resistance.
- Knockdown or knockout of XSER1 enhances broad-spectrum resistance without developmental defects.
- Potential application in breeding pathogen-resistant rice varieties.