Single-Cell cis-Mendelian Randomization Reveals Cell-Specific Genetic Mechanisms Underlying Atopic Dermatitis - PubMed
3 hours ago
- #Single-Cell
- #Mendelian Randomization
- #Atopic Dermatitis
- Single-cell cis-Mendelian randomization used to study atopic dermatitis (AD) genetic mechanisms.
- Identified 303 cell-specific gene-trait associations with limited overlaps across 14 immune cell types.
- Prioritized 35 genes across all cell types, showing distinct regulatory effects compared to bulk transcriptomic approaches.
- Found 22 high-confidence genes with independent mechanisms, including immune-relevant and druggable genes like IL2RA.
- Highlights diverse genetic risk mechanisms for AD at single-cell level, with implications for targeted therapies.