A sesquiterpene-rich essential oil from Cannabis sativa L. attenuates symptoms and neuroinflammation in experimental autoimmune encephalomyelitis model through a CB2-mediated signalling - PubMed
3 hours ago
- #CB2 receptor
- #Cannabis sativa
- #Neuroinflammation
- A sesquiterpene-rich essential oil from Cannabis sativa L. was studied for its effects on symptoms and neuroinflammation in an experimental autoimmune encephalomyelitis (EAE) model.
- The essential oil (EO) contained β-caryophyllene, α-humulene, and caryophyllene oxide as major constituents.
- Intranasal administration of EO alleviated thermal and mechanical hypersensitivity, improved motor function, and had antidepressant- and anxiolytic-like effects in EAE mice.
- EO reduced neuroinflammation and demyelination, increased anti-inflammatory markers (CD206, FoxP3), and restored the IL-17/IL-10 balance in spinal cord and hippocampal tissues.
- The therapeutic effects of EO were mediated through CB2 receptor upregulation, as confirmed by the blockade of effects with CB2 antagonist AM630 but not CB1 antagonist AM251.
- The study suggests potential therapeutic applications of cannabis-derived essential oils in multiple sclerosis (MS) via CB2-mediated pathways.