Consequences of irradiation on blood-brain tumor barrier model of Diffuse Midline Glioma: characterization of physical and metabolic properties - PubMed
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- #Blood-brain barrier
- #Diffuse Midline Glioma
- #Radiotherapy
- Study focuses on the effects of irradiation on the blood-brain tumor barrier model of Diffuse Midline Glioma (DMG).
- Characterizes both physical and metabolic properties post-irradiation.
- Uses human pericytes from the hBPs cell line provided by Professor Takashi Kanda’s group.
- Ethical approvals were obtained from local committees and in accordance with the Declaration of Helsinki.
- CD-34+ stem cells from cord blood were used with consent from families and approval from French authorities.
- Patient-derived cells were obtained under an Institutional Review Board-approved protocol in Spain.
- No competing interests declared by the authors.
- References include epidemiological data on pediatric brain tumors and insights into Diffuse Intrinsic Pontine Glioma (DIPG).