Cytomegalovirus Drives the Development of Cytotoxic CD4+ T Cells in Patients With Multiple Sclerosis - PubMed
4 hours ago
- #CD4+ T Cells
- #Cytomegalovirus
- #Multiple Sclerosis
- Cytomegalovirus (CMV) drives the development of cytotoxic CD4+ T cells (CD4 CTL) in patients with multiple sclerosis (MS).
- CD4 CTL exhibit distinct subsets with varying expression of proinflammatory, cytotoxic, and migratory markers.
- A pathogenic CD4 CTL subset coexpresses EOMES and class I-restricted T-cell-associated molecule, accumulates in MS lesions, and resists natalizumab treatment.
- CMV-seropositive individuals show marked enrichment of highly cytotoxic CD4+ T cells.
- The study provides a phenotypic atlas of CD4 CTL, aiding in understanding their development and identifying potential targets for MS diagnosis and treatment.