Determinants of Septic Shock and 90-Day Mortality after Postoperative Healthcare-Associated Intra-Abdominal Infection: The SEPSI-POP study, a Multicentre Retrospective Study - PubMed
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- #postoperative infection
- #critical care
- #sepsis
- Study examines predictors of septic shock and 90-day mortality in postoperative healthcare-associated intra-abdominal infections (HC-IAIs).
- Multicenter retrospective analysis of 271 adult patients from three French ICUs (2009-2021), median age 65, 75.6% with cancer.
- Septic shock occurred in 57% (154 patients); independent predictors included ASA > II, absence of cancer, recent antibiotic exposure, fungal colonization, and Escherichia coli bacteremia.
- Female sex was protective against septic shock.
- 90-day mortality was 14.4%; independent predictors included ASA > II, older age, higher SOFA score at reoperation, fungal colonization, and treatment failure.
- Effective source control was protective against 90-day mortality.
- Fungal colonization and patient frailty (ASA > II) are shared risk factors for both septic shock and mortality.
- Timely interventions and early identification of high-risk profiles may improve outcomes in postoperative HC-IAI.