Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Psychiatric Disorders: A Systematic Review and Meta-Analysis of Randomised Controlled Trials - PubMed
5 hours ago
- #GLP-1 RAs
- #Psychiatric Disorders
- #Meta-Analysis
- Systematic review and meta-analysis of 86 RCTs with 133,378 participants.
- No significant association found between GLP-1 RAs and psychiatric disorders (RR, 0.96; 95% CI, 0.85-1.08).
- No increased risk for depression, suicide, anxiety, sleep disorders, bipolar disorder, delirium, addictive disorders, or schizophrenia.
- Meta-regression showed no effect of glucose, HbA1c, weight, or BMI changes on psychiatric disorder risk.
- Conclusion: GLP-1 RAs are not linked to psychiatric disorder risks.